2024-12-25 REL RCSB RCSB RCSB 2023-10-05 2024-06-19 2024-06-19 2024-12-25 National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS) 1R35GM142959 United States Zheng W Zhang K Zhu J in-situ cryo-EM structure, mammalian, mitochondria, respiratory supercomplex, proton pumping, membrane protein, electron transport Zheng W Chai P Zhu J Zhang K Nature UK 631 232 239 2024 38811722 doi:10.1038/s41586-024-07488-9 1476-4687 0006 NATUAS 8ugi FULLOVERLAP In-situ cryo-EM structure of respiratory supercomplex by directly imaging mitochondria In-situ cryo-EM structure of respiratory supercomplex by directly imaging mitochondria 0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 41 42 43 44 45 46 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 Sus scrofa NADH-ubiquinone oxidoreductase chain 3 Sus scrofa 0.013026458 1 LEVO (FME)NIMLTLLTNVTLASLLVLIAFWLPQLNAYSEKTSPYECGFDPMGSARLPFSMKFFLVAITFLLFDLEIALLLPLP WASQTNNLKTMLTMALFLLILLAASLAYEWTQKGLEWAE O79880 7.1.1.2 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial Sus scrofa 0.028500184 1 LEVO MRNVSTQVPVSAHRPSRFGQRPRIPGALQRTDRRGCLKAEAEMAALAASGLLRPILALRSSMGAAVQVRFVHPSAATDSP SSSQPAVSQAGAVVSKPTTLPSSRGEYVVAKLDDLVNWARRSSLWPMTFGLACCAVEMMHMAAPRYDMDRFGVVFRASPR QSDVMIVAGTLTNKMAPALRKVYDQMPEPRYVVSMGSCANGGGYYHYSYSVVRGCDRIVPVDIYVPGCPPTAEALLYGIL QLQRKIKREKRLRIWYRR A0A4X1VVS8 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial Sus scrofa 0.030154318 1 LEVO MAAAAAARGCWRGLVGPAAVARVSGRPSVLLLPVRKESAAADTRPTIRPRNDVVHKQLSAFGQYVAEILPKYVQQVQVSC FNELEIFIHPDGVIPVLTFLRDHTNAQFKSLADLTAVDVPTRQNRFEIVYNLLSLRFNSQIRVKTYTDELTPIESSVTVY KAANWYEREIWDMFGVFFANHPDLRRILTGYGFEGHPFRKDFPLSGYVELRYDDEVKRVVAEPVELAQEFRKFDLNSPWE AFPAYRQPPEDLKLEAGDKKPETK A0A286ZNN4 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial Sus scrofa 0.054168074 1 LEVO MAALRALCSLRGVAAQVLRPGAGARLPIQPSRGARQWQPDVEWAEQFGGAVMYPTKETAHWKPPPWNGNYYWPNYFPLLS DVDPPKDTLVSNLTLNFGPQHPAAHGVLRLVMELSGEMVRKCDPHIGLLHRGTEKLIEYKTYLQALPYFDRLDYVSMMCN EQAYSLAVEKLLNIQPPPRAQWIRVLFGEITRLLNHIMAVTTHALDIGAMTPFFWMFEEREKMFEFYERVSGARMHAAYI RPGGVHQDLPLGLLDDIYEFSKNFSFRIDELEEMLTNNRIWRNRTVDIGVVTAEDALNYGFSGVMLRGSGIQWDLRKTQP YDVYDQVEFDVPIGSRGDCYDRYLCRVEEMRQSLRIISQCLNKMPPGEIKVDDAKVSPPKRAEMKTSMESLIHHFKLYTE GYQVPPGATYTAIEAPKGEFGVYLVSDGSSRPYRCKIKAPGFAHLAGLDKMSKGHMLADVVAIIGTQDIVFGEVDR A0A8D0QM68 NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial Sus scrofa 0.027439533 1 LEVO MFLTAALRARATGFTAQWGRHVRNLHKTAVQNGAGGALFVHRDTPENNPDTPFDFTPENYKRIEAIVKNYPEGHKAAAVL PVLDLAQRQNGWLPISAMNKVAEILQVPPMRVYEVATFYTMYNRKPVGKYHIQVCTTTPCMLRNSDSILEAIQKKLGIKV GETTPDKLFTLIEVECLGACVNAPMVQINDNYYEDLTPKDIEEIIDELKAGKIPKPGPRSGRFSCEPAGGLTSLTEPPKG PGFGVQAGL A0A4X1VRV3 NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial Sus scrofa 0.050637766 1 LEVO MLAARRLLGGSLPARVSVRFSGDTTAPKKTSFGSLKDEDRIFTNLYGRHDWRLKGAQSRGDWYKTKEILLKGPDWILGEV KTSGLRGRGGAGFPTGLKWSFMNKPSDGRPKYLVVNADEGEPGTCKDREIIRHDPHKLVEGCLVGGRAMGARAAYIYIRG EFYNEASNLQVAIREAYEAGLIGKNACGSGYDFDVFVVRGAGAYICGEETALIESIEGKQGKPRLKPPFPADVGVFGCPT TVANVETVAVSPTICRRGGAWFASFGRERNSGTKLFNISGHVNHPCTVEEEMSVPLKELIEKHAGGVIGGWDNLLAVIPG GSSTPLIPKSVCETVLMDFDALVQAQTGLGTAAVIVMDRSTDIVKAIARLIEFYKHESCGQCTPCREGVDWMNKVMARFV KGDARPAEIDSLWEISKQIEGHTICALGDGAAWPVQGLIRHFRPELEERMQQFALQHQARQAAS A0A4X1SZP7 NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial Sus scrofa 0.079627398 1 LEVO MLRIPVTRALIGLSKSPKGCVRTTATAASNLIEVFVDGQSVMVEPGTTVLQACEKVGMQIPRFCYHERLSVAGNCRMCLV EIEKAPKVVAACAMPVMKGWNILTNSEKSKKAREGVMEFLLANHPLDCPICDQGGECDLQDQSMMFGSDRSRFLEGKRAV EDKNIGPLVKTIMTRCIQCTRCIRFASEIAGVDDLGTTGRGNDMQVGTYIEKMFMSELSGNIIDICPVGALTSKPYAFTA RPWETRKTESIDVMDAVGSNIVVSTRTGEVMRILPRMHEDINEEWISDKTRFAYDGLKRQRLTQPMIRNEKGLLTYTTWE DALSRVAGMLQSFQGNDVAAIAGGLVDAEALVALKDLLNRVDSDSLCTEEVFPTAGAGTDLRSNYLLNTTIAGVEEADVI LLVGTNPRFEAPLFNARIRKSWLHNDLKVALIGSPVDLTYRYDHLGDSPKILQDIASGNHPFSQILKEAKKPMVVLGSSA LQRSDGTAILAAVSNIAQNIRLSSGVTGDWKVMNILHRIASQVAALDLGYKPGVEAIRKNPPKVLFLLGADGGCITRQDL PKDCFIIYQGHHGDVGAPMADVILPGAAYTEKSATYVNTEGRAQQTKVAVTPPGLAREDWKIIRALSEIAGMTLPYDTLD QVRSRLEEVSPNLVRYDDVEGANYFQQANELSKLVNQQLLADPLVPPQLTIKDFYMTDSISRASQTMAKCVKAVTEGIQA VEEPSIC A0A287ARY3 NADH-ubiquinone oxidoreductase chain 1 Sus scrofa 0.035619434 1 LEVO (FME)FMINILSLIIPILLAVAFLTLVERKVLGYMQLRKGPNVVGPYGLLQPIADALKLVTKEPLRPGTSSISMFIIAPI LGLSLALTMWVPLPMPYPLINMNLGVLFMLAMSSLAVYSILWSGWASNSKYALIGALRAVAQTISYEVTLAIILLSVLLM NGSYTLSTLITTQEHIWMIFTSWPLAMMWFISTLAETNRAPFDLTEGESELVSGFNVEYAAGPFAMFFMAEYANIIMMNA FTAILFLGASHDPHTPELYTINFVLKTLALTITFLWIRASYPRFRYDQLMHLLWKSFLPLTLALCMWHISLPIMTASIPP QS A0A0U1RS44 7.1.1.2 NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial Sus scrofa 0.027135039 1 LEVO MEASQECRLRLSVDRPPPHGKERQRFKMRCLSTPMLLRALAQAQAAHAGHPSARTLHSSAVAATYKFVNMREPSMDMKSV TDRAAQTLLWTELVRGLGMTLSYLFREPATINYPFEKGPLSPRFRGEHALRRYPSGEERCIACKLCEAVCPAQAITIEAE PRADGSRRTTRYDIDMTKCIYCGFCQEACPVDAIVEGPNFEFSTETHEELLYNKEKLLNNGDKWEAEIAANIQADYLYR A0A286ZUN9 NADH-ubiquinone oxidoreductase chain 6 Sus scrofa 0.019021332 1 LEVO MTMYIAFILSTIFVIGFVGFSSKPSPIYGGLGLIVSGGVGCGIVLNFGGSFLGLMVFLIYLGGMLVVFGYTTAMATEMYP EVWVSNKTVFGAFVSGLMMEFCMVYYALKEEEVEIIFKFNGLGDWVIYDTGDSGFFSEEAMGIAALYSYGTWLVIVTGWS LLIGVVVIMEITRGN O79882 NADH-ubiquinone oxidoreductase chain 4L Sus scrofa 0.010855263 1 LEVO (FME)PLVYMNIIMAFAIALAGLLMYRSHLMSSLLCLEGMMLSLFIMSTLIILNTHFTLANMMPIILLVFAACEAALGLS LLVMVSNTYGTDYVQNLNLLQC P56632 7.1.1.2 NADH-ubiquinone oxidoreductase chain 5 Sus scrofa 0.068723508 1 LEVO (FME)NPFASLTLTTLIILTIPIMMSNSNIYKTNLYPNYVKTTVSYAFTLSLVPLLMFMHTGQEMIISNWHWMTLQTVEL SLSFKMDYFSVMFIPVALFVTWSIMEFSMWYMHSDPFINRFFKYLVLFLITMMILVTANNLFQLFIGWEGVGIMSFLLIG WWHGRTDANTAALQAILYNRIGDIGFVLSMAWFLTHSNAWDLQQIFMLNNECPNMPLIGLLLAAAGKSAQFGLHPWLPSA MEGPTPVSALLHSSTMVVAGVFLLIRFYPLMETNKLVQTMTLCLGAITTLFTALCAITQNDIKKIVAFSTSSQLGLMMVT IGINQPHLAFLHICMHAFFKAMLFMCSGSIIHSLNDEQDIRKMGGLYKAMPFTTTALIIGSLALTGMPYLTGFYSKDLII EAVNMSYTNAWALLMTLIATSLTAAYSTRIIFFAFLGKPRFPPLVLINENNPLLINSIKRLLIGSIFAGFIISNNIPPMT VPNTTMPLYMKMTALIVTIMGFMLALELNNTTYYLKFKYPSQTYKFSNMLGYYPSIMHRLPTYHNLSMSQKSASSLLDLI WLETILPKTTSFIQMKMSIMVSNQKGLIKLYFLSFLITIMISMTLFNYHE Q9TDR1 7.1.1.2 NADH-ubiquinone oxidoreductase chain 4 Sus scrofa 0.051887394999999996 1 LEVO (FME)LKIIIPTTMLLPMTWMSKHNMIWINATVHSLLISLISLSLLNQLGENSLNFSLTFFSDSLSAPLLVLTTWLLPLM LMASQSHLSKETTTRKKLYITMLILLQLFLIMTFTATELILFYILFEATLVPTLIIITRWGNQTERLNAGLYFLFYTLAG SLPLLVALVYIQNTTGSLNFLIIHYWSHPLSNSWSNIFMWLACIMAFMVKMPLYGLHLWLPKAHVEAPIAGSMVLAAVLL KLGGYGMMRITTILNPLTNYMAYPFLMLSMWGMIMTSSICLRQTDLKSLIAYSSVSHMALVIVAIMIQTPWSFMGATALM IAHGLTSSMLFCLANTNYERVHSRTMILARGLQTLLPLMATWWLMASLTNLALPPSINLIGELFIITASFSWSNITIILM GMNMMITALYSLYMLITTQRGKYTHHINNIKASFTRENALMALHILPLLLLTLNPKMILGPLY O79881 7.1.1.2 NADH-ubiquinone oxidoreductase chain 2 Sus scrofa 0.039105512 1 LEVO (FME)NPIIYTTLIMTVMSGTMLVMISSHWLLIWIGFEMNLLAMIPVLMKNFNPRATEAATKYFLTQATASMMLMMAIII NLLYSGQWTITKMFNPVAMTMMTMALAMKLGLSPFHFWVPEVTQGISLQAGLLLLTWQKLAPLSVLCQISQSINPNLMLT MAMLSILIGGWGGLNQTQLRKIMAYSSIAHMGWMTAVLPYNTTMTILNLLIYITMTLAMFMLLIHSSATTTLSLSHTWNK MPVITSLMMVTLLSMGGLPPLSGFMPKWMIIQEMTKNESIIMPTLMAMTALLNLYFYMRLAYSSSLTMFPSTNNMKMKWQ FEHTKQMKLLPTMIVLSTLVLPMTPALSSLN O79875 7.1.1.2 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial Sus scrofa 0.040476082000000004 1 LEVO MALRLLRLAPASASAVPRGLGAVAQRVGGIHTGAPCRLQYGPLAFVLGERTTRKLTETSKVITVDGNICSGKGRLAREIA EKLGLRHFPEAGIHYADSTTGDGKPLDVQLSGNCSLEKFYDDPKSNDGNSYRLQSWLYASRLLQYADALEHLLSTGQGVV LERSIYSDFVFLEAMYRQGFIRKQCVEHYNEVKKVTACEYLPPHVVVYVDVPVPEIQSRIQKKGNPHEMKITAAYLQDIE NAYKKTFLPEMSEKCEVLQYSAREAEDAEKVVEDIEYLKCDKGPWPDQDDRTFHRLRMLVQNKLEVLNYTTIPVYLPEIT IGAHQSDRVFQKFTELPGRKYSPGYNEDVGDKWIWLK F1SIS9 NADH:ubiquinone oxidoreductase subunit A9 Sus scrofa 0.042606324 1 LEVO MAAAVHPRVVRAVPMSRSCLAAVATSVSYGPPQRQLHHALIPHGKGGRSSVSGIVATVFGATGFLGRYVVNHLGRMGSQV IVPYRCEPYDTMHLRPMGDLGQIIFMEWNGKDKDSIRKVVEHSNVVINLVGREWETKNFDFEDVFVKIPHAIAQVSKEAG VEKLIHISHLNADIKSPSRYLRSKAVGEKEVRAAFPEATIIKPSDIFGREDRFLNYFASMRWFGGVPLISLGKETVKQPV YIVDVSKGIINAIKDPDAKGKTFAFVGPNRYLLFDLVQYIFAVAYRPFLPYPLPHFAYRWVGRLFEVSPFEPWTTRDKVE RVHMSDMTLPHLPGLEDLGIQATPLELKAIEVLRRHRTYRWLTSEMEDVKPAKTVNI A0A4X1ULW2 NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial Sus scrofa 0.019746514 1 LEVO MAAVSMSVALKQALWGRRAAAVGAVSVSKVPTRLLSTSTWRLAQDQTQDTQLIAVDEKLDITTLTGVPEEHIKTRKVRIF VPARNNMQSGVNNTKKWKMEFDTRERWENPLMGWSSTADPLSNLVLTFSTKEDAVAFAEKNGWSFDVEERKVPKPKSKSY GANFSWNKRTRVSTK A0A4X1SN37 NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial Sus scrofa 0.01334895 1 LEVO MAAVTFLRLLGRSGAGARNLLGGSRCFGVRTSPTGEKVTHTGQAYDDGDYRRVRFSDRQKEVNENFAIDLIAEQPVSEVG SRVISCDGGGGALGHPRVYINLDKETKTGTCGYCGLQFRQPHH A0A4X1THU2 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 Sus scrofa 0.011099798000000001 1 LEVO MAAAAASRGIRAKLGLREIRIHLCQRSPGSQGVRDFIEKRYVELKKANPDLPILIRECSDVQPKLWARYAFGQEKNVSLN NFSADQVTRTLENVLSGKA A0A8D1FN21 NADH:ubiquinone oxidoreductase subunit AB1 Sus scrofa 0.017338211 2 LEVO MAARVLCACVRRLPAAFAPLPRIPTVVAARPLSTTLFPTGAQARSRALQPALVLAQAPSGVTQLCRRYSDAPPLTLEAIK DRVLYVLKLYDKIDPEKLSVNSHFMKDLGLDSLDQVEIIMAMEDEFGFEIPDIDAEKLMCPQEIVDYIADKKDVYE A0A8D1KH26 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 isoform X1 Sus scrofa 0.01332159 1 LEVO MAGLLKKTTGLVGLAVCETPHERLKILYTKILDVLGQIPKNAAYRKYTEQITNEKLGMVKAEPDVKKLEEQLQGGQIEEV ILQAENELSLARKMLRWKPWEPLVEEPPANQWKWPI A0A8D0UWW0 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 Sus scrofa 0.014953313 1 LEVO MAASGLPRAAAAAGTSVKPIFSRDMNEAKRRVRELYRAWYREVPNTVHLFQLDISVKQGRDKVREMFMKNAHVTDPRVVD LLVIKGKMELEETINVWKQRTHIMRFFHETEAPRPTDFLSKFYVGHDP A0A480VKQ8 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 Sus scrofa 0.020064096 1 LEVO MPGIVELPTLEDLKVQEVKVSSSVLKAAAHHYGAQCDKPNKEFMLCRWEEKDPRRCLEEGKLVNQCALDFFRQIKRHCAE PFTEYWTCIDYSGLQLFRHCRKQQAKFDECVLDKLGWVRPDLGELSKVTKVKTDRPLPENPYHSRARPEPNPEAEGDLKP AKHGSRLFFWTM A0A8D0K6B5 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 Sus scrofa 0.014686893999999999 1 LEVO MAKTLLHKYSDIPEGTECHRKAYASTSIGGATGLIVSAYSIALKPPASFLEGVARTGRYTFTSAAIGAIFGLTSCISAQV REKPDDPLNYFIGGCAGGLTLGARTRSYGIGAAACAYMGLTAALVKMGQLEGWQVFAEPKV I3LGM4 NADH:ubiquinone oxidoreductase subunit A13 Sus scrofa 0.016911611 1 LEVO MAASKVKQDMPPPGGYGPIDYKRNLPRRGLSGYSMFAVGIGTLLFGYWSMMKWNRERRRLQIEDFEARIALMPLFQAEKD RRVLQMLRENLEEEAIIMKDVPDWKVGESVFHTTRWVTPMMGELYGLRTNEEILSATYGFIWYT A0A8D0K655 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 Sus scrofa 0.008034373 1 LEVO MWFEILPGIAVMAACLFIPGMATAHIHKFTNGGKEKRVAHFSYQWNLMERDRCISGVNRYHVTKGLENID A0A8D0TJQ4 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 Sus scrofa 0.009225566999999999 1 LEVO MAGRIASFLKNAWAKEPVLVASFAIGGLAIILPSLSPYTNYAIRINRATPYNYPVPLRDDGNMPDVPSHPQDPQGPSLEW LKNL A0A4X1VQ42 NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial Sus scrofa 0.008664053 1 LEVO MAASALFRPFSKLLSSARLPSGSSARSKFYIREPPHGSPDWLKVGLTLGTSVFLWIYLIKQHKEDVLEYKRRNGLE A0A8D0J7S2 NADH dehydrogenase [ubiquinone] 1 subunit C2 Sus scrofa 0.014327655 1 LEVO MTMMSGRPGRVPLQFLPNEARSLPPPKLTDPRLVYMGFLGYCSGLIDNAIRRRPVVSAGLHRQLLYVTSFVFFGYYLLKR QDYMYALRDHDMFAYVKSHPEDFPEKDKKTYGEILEEFHPVR A0A480JRW3 NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 Sus scrofa 0.012506591 1 LEVO MPFFDVQKRLGLDLDRWMTIQSAEQPHKIPGRCHAFEKEWIECAHGIGGIRAEKECKIEFDDFVECLLRQKTMKRLSAIK RQRDKLIKEGKYTPPPHHLGKEDPRP A0A4X1VX77 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 [Sus scrofa] Sus scrofa 0.015371933999999999 1 LEVO MAAAILKLEETRGGGEKCDKNQGVKGRRFMISRSHPSLRAGPANGRSRGHSFRRRWWLGSPLPLVVGVVVGSEAAAFMMN VLQIVRDHWVHILVPVGFVFGCYLDRRSDEKLTAFRNKSLLFKRELRPNEEVTWK A0A8D1IZ33 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial Sus scrofa 0.017384728999999998 1 LEVO MAAGVLGLCARRLLAAAATRGLPAARVRWESGSSRAVIAPSALVGKRPPEPTIRLQEDPDPEDENLYEKNPDSHGYDKDP IVDLWNMRVVFFFGFSIVLVLGSTFVAYLPDYRMQEWARREAERLVKYREANGLPLMESNCFDPNKIQLPEDED A0A8D1EYI7 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial Sus scrofa 0.021587006 1 LEVO MAAMSLLQRASVTAVATLSRSRLGTRFGFGGFLTHGFPKTGAPVRHSGDHGKRLFIIKPSGFYDRRFLKLMRFYILLTGI PVAIGITLVNVFIGEAELADIPEGYVPEHWEYFKHPISRWIARTFYDGPEKNYEKTMAILQIEAEKAELRLKELEVRRLM RARGDGPWYQYPTIDKALIDHSPKTTPDN F1SGC6 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 Sus scrofa 0.015498017 1 LEVO (ACE)SGYTPDEKLRLQQLRELRRRWLKDQELSPREPVLPPRRVWPMEQFWNKFLQDGAPWKNVIYKTYRHSIFAVTHVL IPVWIIHYYLKYHVTAKPYTVVERKPRIFPGDTILETGEVIPLMKEFPDQHH A0A4X1UIV8 NADH:ubiquinone oxidoreductase subunit B2 Sus scrofa 0.011939366 1 LEVO MSPLQRLAPFTRVGGRFLRGRGAGVAGGGGVRHAGGGVHIEPRYRQFPQLTRSQLIQAEFFSATMWFWILWRFWHDSDAV LGHFPYPDPSQWTDEELGILPDDED A0A8D1G9F4 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 Sus scrofa 0.011128514999999999 1 LEVO MAHGHGHEHGHSKMELPDYKQWKIEGTPLETVQEKLAARGLRDPWGRNEAWRYSGGFANNVSFVGALLKGFKWGFAAFVV AVGAEYYLESQNKDKKHH A0A4X1VD84 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial Sus scrofa 0.021658447 1 LEVO MASAKAGVLGVRWLQRAARKVVPLGARTASHVTKDMFPGPYPKTPEERAAAAKKYNMRVEDYEPYPDDGMGYGDYPKLPD RSQQERDPWYDWDHPDLRLNWGEPIHWDLDMYIRNRVDTSPTPVSWNTMCKHLSGFVAFMLFMFWVGEIYPSYQPVGPKQ YPYNDLYLERGGDPTKEPEPVVHYEI B8Y651 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 Sus scrofa 0.01511735 1 LEVO MSFPKYKPSRLATLPATLDPAEYDISPETRKAQAERLAIRSRLKREYLLQYNDPNRLGVIEDPALIRWTYARSANIYPNF RPTPKTSLLGALFGIGPLFFWYYVFKTDRDKKEKLIQEGKLDQTFNISY A0A4X1T6M0 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 Sus scrofa 0.021864905999999996 1 LEVO MAFSAPAAYLTHQQKVLRLYKRALRHLESWCVHRDKYRYFACLMRARFDEHKNEKDMVKATQLLRQAEEEFWYGQHPQPY IFPESPGGTSYERYECYKVPEWCLDDWHPSEKAMYPDYFAKREQWKRLRRESWEREVKQLQEETPPGGPRTEALPPARKE GDLPPLWWHIVTRPRERPM K7GSE5 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 Sus scrofa 0.016567046999999998 1 LEVO (MYR)GAHLARRYLGDASKEPDPLRMPTFPPDYGFPERKEREMVATQQEMNDAQLMLQQRDYCAHYLIQLLKCKRDSFPN FLACKHEQHDWDYCEHLDYVKRMKEFERERRLLQRKKRREQREAEMARGQGPGEVAPEMAL F1SCH1 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 Sus scrofa 0.020944768 1 LEVO MPDSWDKDVYPEPPRRTPAPAPQTSLPNPVTYLTKIFDLLVDRPVTLAREFIEQQHAKNRYYYYHREFRRVPDITECEEK DILCMFEAEMQWRRDYKVDQEIVNIIQERLKACQQREGESYRQNCAKELEQFTQVSKAFQDRYSDLGAHYSARKCLAKQK QRMLAERKAAKEAAAA A0A8D0R7A9 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 Sus scrofa 0.017162438999999998 1 LEVO MELVQVLRRGLQQVSGHGGLRGYLRVLFRANDVRVGTLVGEDKYGNKYYEDNKQFFGRHRWVIYTTEMNGRDTFWDVDGS MVPPEWHRWLHCMTDDPPTTKPPTARKYIWTNHKFNVSGTPQQYVPYSTTRKKIQEWVPPSTPYK F1SQP4 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 Sus scrofa 0.01264859 1 LEVO MASATRVIQLLRNWASGRDLQAKLQLRYQEISKRTQPPPKLPVGPSHKLSNNYYCTRDGRREAMPPSIVMSSQKVLASGK PAESSAVAETEKKAVTPAPPIKRWELSKDQPYL A0A8W4F7N8 NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial Sus scrofa 0.048217836 1 LEVO MAASLLLRQGRARALKTVLLEGGVFRGLAPAVSLSAESGRNEKERPPNPKKQSPPKNVVAAQEGGTPLATPAAPELSQQL SSPTSPPAAARPGGTLAPPNPGDSTLFTDRGRPRFPSRKTLVEFPRKVLSPFSQQGSDSAATQASRGRAGDATSSSSSSS SSDSESDDEEEGDGSEAVRPVKSTSPGGSPKAEAPRSLAGGAPQTGVPAEARPGPQQPHPDLAAAERPRQAKGKGGSGAP EDRRAPKAAAPGSRGGPGAARQSETPSQKIPRSEEADAESQKPPEVKTSLPDPTKSGLSTAPRGGPASAEPAATPAGARL PATPLETGERPLGERVPEPGGQVASPLFSRAPLGGQAAEGVAEAKGELLEGRPLVQGPKAVPDGQDEGAEKKALRPEEEA GIAGDAAPGTAGRDATQEPTPAAAAAEPFDNSTYRNLQHHEYSTYTFLDLNVELSKFRMPQPSSGRQSPRH A0A4X1TE42 Cytochrome b-c1 complex subunit 1, mitochondrial Sus scrofa 0.052756319999999995 2 LEVO MAASAVCRVAGTGSRVLLRTCRSPALLRSPALRGTATYAQALQSVPETQVSQLDNGLRVASEQSSQPTCTVGVWIDAGSR YENEKNNGAGYFVEHLAFKGTKNRPGSALEKEVESMGAHLNAYSTREHTAYYIKALSKDLPKAVELLADIVQNCSLEDSQ IEKERDVILQELQENDSSMRDVVFDYLHATAFQGTPLAQSVEGPSENVRKLSRADLTEYVSQHYKAPRMVLAAAGGVEHR QLLDLAQKHFSSLSGTYVEDAVPAFTPCRFTGSEIRHRDDALPLAHVAIAVEGPGWANPDNVPLQVANAIIGHYDSTYGG GTHMSSTLASVAATRKLCQSFQTFNICYAETGLLGAHFVCDNMSIDDMMFFLQGQWMRLCTSATESEVVRGKNILRNALV SHLDGTTPVCEDIGRSLLTYGRRIPLAEWESRIAEVDASVVREVCSKYFYDQCPAVAGLGPIEQLPDYNRIRSGMFWLRF A0A8D0PK14 Cytochrome b-c1 complex subunit 2, mitochondrial Sus scrofa 0.048262434 2 LEVO MKLITRAGSFSRFYSLKVAPKALASAAPAGVPLQPQDLEFTRLPNGLVIASLENYAPASRIGLFIKAGSRYEDSNNLGTS HLLRLASSLTTKGASSFKITRGIEAVGGKLSVTSTRESMAYTVECLRDDIEILMEFLLNVTAAPEFRRWEVAALQSQLRI DKAVAFQNPQAQVLENLHAAAYRNALANSLYCPDYRIGKVTPDQLHYYVQNHFTSARMALIGLGVSHPVLKQVAERFLNM RGGLGLSGAKAKYRGGEIRDQNGDSLVHAALVAESAATGSAEANAFSVLQHVLGAGPHVKRGSNATSSLYQAVAKGVHQP FDVSAFNASYSDSGLFGIYTISQAASAGDVIKSAYDQVKTIAQGNLSNTDVQAAKNKLKAGYLMSVESSEGFLDEVGSQA LVAGSYVQPSTVLQQIDSVADADVINAAKKFVSGRKSMAASGNLGHTPFVDEL F1RPD2 Cytochrome b Sus scrofa 0.042840714999999994 2 LEVO MTNIRKSHPLMKIINNAFIDLPAPSNISSWWNFGSLLGICLILQILTGLFLAMHYTSDTTTAFSSVTHICRDVNYGWVIR YLHANGASMFFICLFIHVGRGLYYGSYMFLETWNIGVVLLFTVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGTDL VEWIWGGFSVDKATLTRFFAFHFILPFIITALAAVHLLFLHETGSNNPTGISSDMDKIPFHPYYTIKDILGALFMMLILL ILVLFSPDLLGDPDNYTPANPLNTPPHIKPEWYFLFAYAILRSIPNKLGGVLALVASILILILMPMLHTSKQRSMMFRPL SQCLFWMLVADLITLTWIGGQPVEHPFIIIGQLASILYFLIILVLMPITSIIENNLLKW Q1HBG9 Cytochrome c1, heme protein, mitochondrial Sus scrofa 0.035359749999999995 2 LEVO MSAAAAASLRGAVLGPRGAGLPGARARGLLCGPRPGQLPLRTPQALSLSSKSGLSRGRKVILSALGMLAAGGAGLAVALH SAVSATDLELHAPSYPWSHRGLLSSLDHTSIRRGFQVYKQVCSSCHSMDYVAYRHLVGVCYTEEEAKALAEEVEVQDGPN EDGEMFMRPGKLSDYFPKPYPNPEAARAANNGALPPDLSYIVRARHGGEDYVFSLLTGYCEPPTGVSLREGLYFNPYFPG QAIAMAPPIYNEVLEFDDGTPATMSQVAKDVCTFLRWASEPEHDHRKRMGLKMLMMMGLLLPLVYAMKRHKWSVLKSRKL AYRPP A0A4X1UNI7 Cytochrome b-c1 complex subunit Rieske, mitochondrial Sus scrofa 0.029492599999999997 4 LEVO MLSVASRSGPFAPVLSATSRGVAGALRPLVQAALPATSESPVLDAKRSFLCRESLSGQAAGRPLVASVGLNVPASVRYSH TDIRVPDFSDYRRAEVLDSTKSSKESSDARKGFSYLITATTTVGVAYAAKNAVSQFVSSMSASADVLAMSKIEIKLSDIP EGKNMAFKWRGKPLFVRHRTKKEIDQEAAVEVSQLRDPQHDLERVKKPEWVILIGVCTHLGCVPIANAGDFGGYYCPCHG SHYDASGRIRKGPAPLNLEVPTYEFTSDDLVIVG A0A480EHC1 Cytochrome b-c1 complex subunit 7 Sus scrofa 0.013587549 2 LEVO MASRPAVAASSKWLEGIRKWYYNAAGFNKLGLMRDDTIYEDDDVKEAIRRLPENLYNDRVFRIKRALDLTMRQQILPKEQ WTKYEEDKFYLEPYLKEVIRERKEREEWAKK A0A286ZPR8 Cytochrome b-c1 complex subunit 8 Sus scrofa 0.009784339 2 LEVO MGREFGHLTRMRHVITYSLSPFEQRAFPHYFTKGIPNVLRRTRACILRVAPPFVVFYLVYTWGTQEFEKSKRKNPAAYEN DK A0A8D0SHY6 Cytochrome b-c1 complex subunit 6, mitochondrial Sus scrofa 0.010685802999999999 2 LEVO MGLEDEQRMLTGSGDPKEEEEEEEELVDPLTTVREQCEQIEKCIKARERLELCDQRVSSRSQTEEDCTEELFDFLHARDH CVAHKLFNSLK A0A8D1JI21 Ubiquinol-cytochrome c reductase complex 7.2 kDa protein Sus scrofa 0.00741253 2 LEVO MAAPTLTARLYSLLFRRTSTFALTIAVGALFFERAFDQGADAIYEHINQGKLWKHIKHKYENKE A0A8D1J3N6 Cytochrome b-c1 complex subunit 10 Sus scrofa 0.006560654 2 LEVO MLSRFLGPRYRELARNWIPTASMWGAVGAVGLVWATDWRLILDWVPYINGKFKKED F1SDI2 Cytochrome c oxidase subunit 1 Sus scrofa 0.056992711 1 LEVO MFVNRWLYSTNHKDIGTLYLLFGAWAGMVGTALSLLIRAELGQPGTLLGDDQIYNVIVTAHAFVMIFFMVMPIMIGGFGN WLVPLMIGAPDMAFPRMNNMSFWLLPPSFLLLLASSMVEAGAGTGWTVYPPLAGNLAHAGASVDLTIFSLHLAGVSSILG AINFITTIINMKPPAMSQYQTPLFVWSVLITAVLLLLSLPVLAAGITMLLTDRNLNTTFFDPAGGGDPILYQHLFWFFGH PEVYILILPGFGMISHIVTYYSGKKEPFGYMGMVWAMMSIGFLGFIVWAHHMFTVGMDVDTRAYFTSATMIIAIPTGVKV FSWLATLHGGNIKWSPAMLWALGFIFLFTVGGLTGIVLANSSLDIVLHDTYYVVAHFHYVLSMGAVFAIMGGFVHWFPLF SGYTLNQAWAKIHFVIMFVGVNMTFFPQHFLGLSGMPRRYSDYPDAYTAWNTISSMGSFISLTAVMLMIFIIWEAFASKR EVSAVELTSTNLEWLHGCPPPYHTFEEPTYINLK O79876 Cytochrome c oxidase subunit 2 Sus scrofa 0.026130471 1 LEVO (FME)AYPFQLGFQDATSPIMEELLHFHDHTLMIVFLISSLVLYIISLMLTTKLTHTSTMDAQEVETIWTILPAIILILI ALPSLRILYMMDEINNPALTVKTMGHQWYWSYEYTDYEDLTFDSYMIPTSDLKPGEMRLLEVDNRVVLPMEMTIRMLVSS EDVLHSWAVPSLGLKTDAIPGRLNQTTLMSTRPGLYYGQCSEICGSNHSFMPIVLELVPLKYFEKWSTSML P50667 7.1.1.9 Cytochrome c oxidase subunit 3 Sus scrofa 0.029753361 1 LEVO MTHQTHAYHMVNPSPWPLTGALSALLMTSGLTMWFHFNSMLLLSLGLLTNTLTMYQWWRDIIRESTFQGHHTSVVQKGLR YGMILFIISEVLFFTGFFWAFYHSSLAPTPELGGCWPPTGIHPLNPLEVPLLNTSILLASGVSITWAHHSLMEGDRKHMI QALSITIALGVYFTLLQASEYYEAPFTISDGVYGSTFFVATGFHGLHVIIGSTFLAVCLLRQLKFHFTSNHHFGFEAAAW YWHFVDVVWLFLYVSIYWWGS Q35916 Cytochrome c oxidase subunit 4 Sus scrofa 0.019670664 1 LEVO MLATRVFNLIGRRAISTSVCVRAHGSVVKSEDYALPVYVDRRDYPLPDVAHVKNLSASQKALKEKEKASWSSLSMDEKVE LYRLKFNESFAEMNRSTNEWKTIVGTALFFIGFTALLLIWEKHYVYGPIPHTFEEEWVAKQTKRMLDMKVAPIQGFSAKW DYDKNEWKK A0A4X1T8J9 Cytochrome c oxidase subunit 5A, mitochondrial Sus scrofa 0.016771195 1 LEVO MLGAAVRRCSVAAAAVARASPRGLLHPTPTPGPAAAIQSIRCYSHGSHETDEEFDARWVTYFNKPDIDAWELRKGMNTLV GYDLVPEPKIIDAALRACRRLNDFASAVRILEVVKDKAGPHKEIYPYVIQELRPTLNELGISTPEELGLDKV F1SJ34 Cytochrome c oxidase subunit 5B, mitochondrial Sus scrofa 0.013801782999999998 1 LEVO MASRLLRGAGALAAQTLRARGPNGVAVVRSMASGGGVPTDEEQATGLEREVMMAARKGLDPYNILAPKAASGTKEDPNLV PSITNKRIVGCICEEDNSTVIWFWVHKGETQRCPSCGTHYKLVSHQLAH Q5S3G4 Cytochrome c oxidase subunit 6A2 Sus scrofa 0.01087637 1 LEVO MALPLRSLSRGLASAAKGDHGGTGARTWRFLTFGLALPSVALCTLNSWLHSGHHHRPEFIPYHHLRIRTKPYSWGDGNHT LFHNPRVNPLPTGYEQP A0A287AEB7 Cytochrome c oxidase subunit 6B1 Sus scrofa 0.010204455999999999 1 LEVO MAEDIQTKIKNYQTAPFDSRFPNQNQTRNCWQNYLDFHRCEKAMTAKGGDVSVCEWYRRVYKSFCPISWVSAWDDRRAEG TFPGKI A1XQT1 Cytochrome c oxidase subunit 6C Sus scrofa 0.008617122 1 LEVO MATSSLTKPQMRGLLAKRLRFHIVGAFIVSLGVATFYKFAVAEPRKKAYADFYRNYDSMKDFEEMRKAGIFQSAK A0A4X1TXH1 Cytochrome c oxidase subunit 7A1, mitochondrial Sus scrofa 0.009028478999999999 1 LEVO MRALRVSQALVRSFSSTARNRLENRVAEKQKIFQADNDLPVHLKGGATDNILYRVTMTLCLGGTVYSLYCLGWASFPHKK Q8SPJ9 Cytochrome c oxidase subunit 7B Sus scrofa 0.009169476 1 LEVO MFPLAKNALSRLRVRNIQQTMARQNHQKRAPDFHDKYGNAILASGATFCVAVWAYTATQIGIEWNLSPVGRVTPKEWREE A0A287BJ57 Cytochrome c oxidase subunit 7C, mitochondrial Sus scrofa 0.007358661 1 LEVO MLGQSIRRFTTSVVRRSHYEEGPGKNLPFSVENKWRLLAMMTLYFGSGFAAPFFIVRHQLLKK Q1W0Y2 Cytochrome c oxidase subunit 8 Sus scrofa 0.007615939 1 LEVO MLRLAPTVRLLQAPLGGWVVPKAHIYAKPARTPTSPTEQAIGLSVTFLSFLIPAGWVLSHLDHYKRSSAA A1XQT4 Cytochrome c oxidase subunit NDUFA4 Sus scrofa 0.009322771 1 LEVO MLRQIITQAKKHPSLIPLFVFIGAGGTGAALYVTRLALFNPDVCWDRKNNPEPWNKLGPNDQYKFFAVNVDYSKLKKEGP DF A1XQS3 1,2-Distearoyl-sn-glycerophosphoethanolamine 0.000748065 27 3PE 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE 0.0007901449999999999 15 PC1 IRON/SULFUR CLUSTER 0.00035163999999999996 6 SF4 FE2/S2 (INORGANIC) CLUSTER 0.00017581999999999998 4 FES FLAVIN MONONUCLEOTIDE 0.00045634399999999997 1 FMN POTASSIUM ION 3.9098e-05 1 K CARDIOLIPIN 0.0014640429999999997 15 CDL GUANOSINE-5'-TRIPHOSPHATE 0.0005231799999999999 1 GTP MAGNESIUM ION 2.4305e-05 2 MG NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE 0.000745421 1 NDP ZINC ION 6.5409e-05 2 ZN ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate 0.000584703 2 EHZ N-ACETYLMETHIONINE 0.00019124799999999998 1 AME MYRISTIC ACID 0.000228371 1 MYR PROTOPORPHYRIN IX CONTAINING FE 0.000616487 4 HEM HEME C 0.0006185030000000001 2 HEC (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE 0.0007490069999999999 15 PGV HEME-A 0.000852837 2 HEA COPPER (II) ION 6.354599999999999e-05 1 CU SODIUM ION 2.299e-05 1 NA DINUCLEAR COPPER ION 0.00012709199999999998 1 CUA (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE 0.0007590679999999999 1 PSC (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE 0.0007680549999999999 2 PEK PHOSPHATE ION 9.4971e-05 1 PO4 water 1.8015e-05 6327 HOH singleParticle particle 7.0 ETHANE FEI TITAN KRIOS FLOOD BEAM BRIGHT FIELD FIELD EMISSION GUN 300 2.7 1.3 3.0 GATAN K3 BIOQUANTUM (6k x 4k) 50.0 1 2.1 FSC 0.143 CUT-OFF 400000 MAXIMUM LIKELIHOOD MAXIMUM LIKELIHOOD emd_42226_additional_3.map.gz 1 IMAGE STORED AS FLOATING POINT NUMBER (4 BYTES) 512 512 512 -90 -90 -90 512 512 512 532.48 532.48 532.48 90.0 90.0 90.0 X Y Z -0.84821004 1.3614713 0.00040423582 0.017628556 1.04 1.04 1.04 AUTHOR ::::EMDATABANK.org::::EMD-42226:::: In-situ structure of supercomplex in respiratory chain ( typeA ) emd_42226_additional_2.map.gz 1 IMAGE STORED AS FLOATING POINT NUMBER (4 BYTES) 512 512 512 -90 -90 -90 512 512 512 532.48 532.48 532.48 90.0 90.0 90.0 X Y Z -0.6031598 1.3264573 0.0006477885 0.017099421 1.04 1.04 1.04 AUTHOR ::::EMDATABANK.org::::EMD-42226:::: In-situ structure of supercomplex in respiratory chain ( typeA ) emd_42226_additional_1.map.gz 1 IMAGE STORED AS FLOATING POINT NUMBER (4 BYTES) 512 512 512 -90 -90 -90 512 512 512 532.48 532.48 532.48 90.0 90.0 90.0 X Y Z -2.180654 2.300952 0.00017251312 0.012493354 1.04 1.04 1.04 AUTHOR ::::EMDATABANK.org::::EMD-42226:::: In-situ structure of supercomplex in respiratory chain ( typeA )